Steroids Corticosteroids Prednisone Cortisone Dexamethasone —Sensitize Microglia & Prime Glial Over-Responsiveness

08/29/2016 — Nancy Sajben MD

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Glucocorticoids prime later immune &

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glial over-responsiveness that

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 induces cellular damage/stress in the brain

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The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights.

Frank MG, Watkins LR, Maier SF.
Curr Opin Endocrinol Diabetes Obes. 2015 Aug;22(4):300-5. doi: 10.1097/MED.0000000000000168. Review.
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“In light of these findings, we propose a model of glucocorticoid-induced neuroinflammatory priming whereby stress and glucocorticoids induce cellular damage/stress in the brain, the products of which prime the NLRP3 inflammasome. “
PMID: 
26087336 

Free PMC Article

Select item 255593332.
Barrientos RM, Thompson VM, Kitt MM, Amat J, Hale MW, Frank MG, Crysdale NY, Stamper CE, Hennessey PA, Watkins LR, Spencer RL, Lowry CA, Maier SF.
Neurobiol Aging. 2015 Mar;36(3):1483-95. doi: 10.1016/j.neurobiolaging.2014.12.003. Epub 2014 Dec 11.
PMID: 
25559333 

Free PMC Article

Select item 254331703.
Fonken LK, Frank MG, Kitt MM, Barrientos RM, Watkins LR, Maier SF.
Brain Behav Immun. 2015 Mar;45:171-9. doi: 10.1016/j.bbi.2014.11.009. Epub 2014 Nov 26.
PMID: 
25433170 

Free PMC Article

Select item 244854914.
Frank MG, Hershman SA, Weber MD, Watkins LR, Maier SF.
Psychoneuroendocrinology. 2014 Feb;40:191-200. doi: 10.1016/j.psyneuen.2013.11.006. Epub 2013 Nov 27.
PMID: 
24485491 

Free PMC Article

Select item 234590265.
Frank MG, Watkins LR, Maier SF.
Brain Behav Immun. 2013 Oct;33:1-6. doi: 10.1016/j.bbi.2013.02.004. Epub 2013 Mar 1. Review.
PMID: 
23459026
Select item 220412966.
Frank MG, Thompson BM, Watkins LR, Maier SF.
Brain Behav Immun. 2012 Feb;26(2):337-45. doi: 10.1016/j.bbi.2011.10.005. Epub 2011 Oct 24.
PMID: 
22041296
Select item 219074187.
Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR.
J Neuroimmunol. 2011 Oct 28;239(1-2):53-60. doi: 10.1016/j.jneuroim.2011.08.011. Epub 2011 Sep 9.
PMID: 
21907418 

Free PMC Article

Select item 215361238.
Loram LC, Taylor FR, Strand KA, Frank MG, Sholar P, Harrison JA, Maier SF, Watkins LR.
Brain Behav Immun. 2011 Oct;25(7):1408-15. doi: 10.1016/j.bbi.2011.04.013. Epub 2011 Apr 23.
PMID: 
21536123 

Free PMC Article

Select item 212569559.
Frank MG, Watkins LR, Maier SF.
Brain Behav Immun. 2011 Jun;25 Suppl 1:S21-8. doi: 10.1016/j.bbi.2011.01.005. Epub 2011 Jan 21. Review.
PMID: 
21256955
Select item 1964707010.
Frank MG, Miguel ZD, Watkins LR, Maier SF.
Brain Behav Immun. 2010 Jan;24(1):19-30. doi: 10.1016/j.bbi.2009.07.008. Epub 2009 Jul 30.
PMID: 
19647070

Select item 1738382611.

Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression.

Frank MG, Der-Avakian A, Bland ST, Watkins LR, Maier SF.
Psychoneuroendocrinology. 2007 May;32(4):376-84. Epub 2007 Mar 26.
PMID: 
17383826

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