Donate to RSDSA to relieve neuropathic pain

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It is always a good time to make a tax-deductible 2014 financial contribution to RSDS.org.

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The link at top banner takes you to the RSDSA and some ways to donate directly to them.

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RSD is Reflex Sympathetic Dystrophy, a severe form of neuropathic pain. It was renamed in the mid 1990’s as Complex Regional Pain Syndrome, CRPS, but continues to go by the previous name RSD.

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Treatment for this form of neuropathic pain is not specific to RSD. The same treatment principles apply to all forms of neuropathic pain.

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Your support can help so many others regardless of their diagnosis. Please give today.

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I am not affiliated with the Reflex Sympathetic Dystrophy Association. I recommend them because they support some of the best research in pain, work that has contributed greatly to the understanding of newer approaches to treatment. And because their work and collaboration together with other organizations of people with pain, with chronic fatigue, with dystonia, and fibromyalgia helps all.

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The material on this site is for informational purposes only.

It is not a substitute for medical advice,

diagnosis or treatment provided by a qualified health care provider.

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Please understand that it is not legal for me

to give medical advice without a consultation.

If you wish an appointment, please telephone my office.

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For My Home Page, click here:  Welcome to my Weblog on Pain Management!

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PEA (palmitoylethanolamide) inhibits TLR4

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New insight into the mechanism of action of palmitoylethanolamide was presented in 2013 at EFIC, a Congress for European Pain Specialists:

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“… Dr Svik Assaw and colleagues from the School of Life Sciences, Medical School, University of Nottingham, United Kingdom presented new exciting data on the mechanism of action of the fatty acid amide N-Palmitoyethanoalamide (PEA) and presented the effects of PEA after activation of toll-like receptors (TLRs) by the inflammatory substance carrageenan.”

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1. PEA inhibits chemotaxis of monocytes, but not neutrophils (clearly a sign that PEA downregulates chronic inflammation but not acute inflammation)

2. PEA decrease in the carrageenan induced induction of the pro-inflammatory genes IL-1b, CCL4 and NOS2 in the inflamed skin.

3. PEA also blocks CCL4 induced monocyte migration in a chemotaxis assay.

4. PEA clearly modulates the TLR4 mediated inflammatory responses and dose-related inhibits inflammatory evoked TNFa and IL-1b gene expression.”

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~~~~~

The material on this site is for informational purposes only.

It is not a substitute for medical advice,

diagnosis or treatment provided by a qualified health care provider.

~~~~~

Please understand that it is not legal for me

to give medical advice without a consultation.

If you wish an appointment, please telephone my office.

.

For My Home Page, click here:  Welcome to my Weblog on Pain Management!

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